Pleomorphic invasive lobular breast carcinoma: Prognosis and characteristics compared with classical invasive lobular breast carcinoma.

e13094Background: Pleomorphic lobular carcinoma (PLC) is a rare type of invasive lobular breast carcinoma that has traditionally been thought to have a worse prognosis as compared to classical lobular carcinoma (cILC), but prior studies are small with conflicting results. We seek to examine differences in clinical characteristics and progression-free and overall survival between PLC and cILC to guide treatment decisions. Methods: From retrospective review of all women with invasive breast carcinoma seeking care at a single institution from 1998-2012, 146 women with PLC and 262 women with cILC were identified. Analysis was performed to examine differences in clinicopathologic variables and progression-free and overall survival between the two groups. Results: On average, the PLC group had a significantly higher pathological stage, prevalence of lymphovascular invasion, proportion of node positive disease and proportion of mastectomy as compared to lumpectomy. There were no differences in age at diagnosis, ...