Investigation of the Medicinal Potentials of Syzygium jambos (L.) Extract and Characterization of the Isolated Compounds

Syzygium jambos (L.) Alstone belonging to the Myrtaceae family have been investigated for isolation of their secondary metabolites and evaluation of their biological activities. A total of three compounds have been isolated. The isolated compounds were identified by extensive analysis of their high resolution 1H-NMR spectroscopic data.The dried stem barks of Syzygium jambos was extracted with methanol. The concentrated methanolic extract was then partitioned with vacuum liquid chromatography. The first investigation was conducted with the VLC fraction-6 afforded one pentacyclic triterpenes (SJ-61), VLC fraction-9 afforded a sitosterol (SJ-92) and VLC fraction-16 afforded a triterpene 3-nor-2,3-fridelan derivative (SJ-184). In the brine shrimp lethality bioassay, The LC50 values were found to be 6.97, 18.07, 64.943, 247.596 and 12.75mg/ml for crude methanolic extract, carbon tetrachloride, chloroform and n-hexane soluble fractions of methanolic extract of Syzygium jambos respectively representing methanolic extract fraction as highly cytotoxic.