Exposure Level of Neonicotinoid Insecticides in the Food Chain and the Evaluation of Their Human Health Impact and Environmental Risk: An Overview

Neonicotinoid insecticides (neonics) were the most rapidly growing class of insecticides over the past few decades, and are used mainly for vegetables, fruits, and grains. Although neonics exhibit lower toxicity in mammals and humans compared to traditional insecticides, increasing numbers of studies are demonstrating that neonics may accumulate in the food chain and environmental media. Long-term exposure to neonics may raise potential risks to animals and even to humans. The present report reviews the development, application, and prohibition of neonics in the farmland ecosystem, and summarizes the exposure level and harmful effects of these insecticides in the food chain. In addition, the present review analyzes and summarizes the evaluation of the human health impact and environmental risk of the neonics, and overviews the unresolved problems and future research directions in this field. The aim of the present report was to review the exposure level, potential toxicity, human health impact, and environmental risk assessment of neonics in various media in order to provide reliable technical support for strengthening the environmental and food safety supervision and green pesticide designing.