Effect of Acorus tatarinowii schott on ultrastructure and permeability of blood-brain barrier.

Objective:To explore the influence of Acorus tatarinowii schott on ultrastructure and permeability of BBB.Method:The ultrastructure and permeability of BBB on rats with A.tatarinowii by electron microscope were observed.The even′s blue(EB) and sodium phenytoin in brain was determined by UV and HPLC-MS.Result:After give A.tatarinowii,tight junctions of the endothelial cell opened in cotex,and the concentration of EB and sodium phenytoin in brain are significant increased.Conclusion:A.tatarinowii can increase the permeability of BBB,and show its‘Kaiqiao’effect.