Synthesis of high throughput ibuprofen nanoparticles via supercritical CO 2 processing

High throughput ibuprofen nanoparticles with a yield up to 80 % (w/w) are synthesized via supersonic jet expansion of the supercritical CO2 processing. The effect of four different surfactants on the size of ibuprofen nanoparticles were investigated. Drop casting of these aqueous solutions on a quartz substrate and resulted in stable, viscous liquid films observed by optical, atomic force microscopy (AFM) and scanning electron microscopy (SEM). X-ray diffraction (XRD) and confocal Raman confirmed that these nanoparticles have retained their structural and chemical identity after rapid expansion of a supercritical solution (RESS) processing.