Mechanodegradation of polymers: a limiting factor of mechanochemical activation in the production of amorphous solid dispersions by cryomilling.

Timothy Pas,Bart Smeets,Herman Ramon,Ann Van Schepdael,Marwa F. Mansour,Robin Koekoekx,Christian Clasen,Bjorn Vergauwen,Guy Van den Mooter

Mechanodegradation of polymers: a limiting factor of mechanochemical activation in the production of amorphous solid dispersions by cryomilling.

2020

Timothy Pas
Bart Smeets
Herman Ramon
Ann Van Schepdael
Marwa F. Mansour
Robin Koekoekx
Christian Clasen
Bjorn Vergauwen
Guy Van den Mooter

In this study we report on the influence of mechanochemical activation on the chemical stability of amorphous solid dispersions made up of indomethacin and HPMC, PVP, PVPVA or Soluplus®. In agreeme...

Keywords:

Biochemistry
Chemistry
Limiting factor
Chemical engineering
Amorphous solid
Chemical stability
Dispersion (chemistry)
Polymer

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