N-Acylethanolamine Acid Amidase (NAAA): Mechanism of Palmitoylethanolamide Hydrolysis Revealed by Mechanistic Simulations

Laura Scalvini,Andrea Ghidini,Alessio Lodola,Donatella Callegari,Silvia Rivara,Daniele Piomelli,Marco Mor

N-Acylethanolamine Acid Amidase (NAAA): Mechanism of Palmitoylethanolamide Hydrolysis Revealed by Mechanistic Simulations

2020

Laura Scalvini
Andrea Ghidini
Alessio Lodola
Donatella Callegari
Silvia Rivara
Daniele Piomelli
Marco Mor

The N-terminal cysteine hydrolase N-acylethanolamine acid amidase (NAAA) catalyzes the hydrolytic deactivation of the lipid messenger, palmitoylethanolamide (PEA), with optimal activity at acidic p...

Keywords:

N-acylethanolamine acid amidase
Cysteine
Hydrolase
Palmitoylethanolamide
Hydrolysis
Chemistry
Stereochemistry
Amidase

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