Furan fragment isomerized mexicanolide-type Limonoids from the stem barks of Khaya senegalensis

Abstract Four new mexicanolide-type limonoids with isomerized furan fragment khaysenelides G–J (1–4) were isolated from the stem barks of Khaya senegalensis . Their structures were elucidated on the basis of (1D and 2D) NMR and HRESIMS, and the normal furan rings in 1 - 4 were isomerized to hydroxybutenolide moieties. Bioactivities screening of new compounds indicated that 1 showed potent cytotoxicities against MDA-MB-231 and HepG2 human cancer cell lines with IC 50 values of 6.02 and 8.98 μM, and significant NO inhibitory activities in LPS-activated RAW 264.7 macrophages with IC 50 values of 3.51 μM.