Pathogenic and adaptive changes of the heart in regional myocardial ischemia and postischemic myocardial reperfusion

: The evidence is presented and on development of both adaptive and pathogenic changes in the heart in its regional ischemia followed by renewal of circulation in major branches of coronary arteries. Cellular and molecular mechanisms of cardiac changes are characterized: energy supply to cardiomyocytes; their membrane physico-chemical status and structure, enzymes activity, ion-liquid balance, electrophysiological parameters; genetic program of myocardial cells; mechanisms of neurohumoral regulation. Mechanisms and role of the phenomenon of hormone-neuromediator dissociation of catecholamines (adrenaline and noradrenaline) correlations in long-term ischemia and reperfusion of the myocardium are described.