UNİLATERAL HERPES KERATİTİ OLAN HASTALARIN BİLATERAL OKÜLER YÜZEY VE GÖZYAŞI OSMOLARİTESİNİN DEĞERLENDİRİLMESİ Evaluation of Bilateral Ocular Surface and Tear Osmolarity in Patients With Unilateral Herpes Keratitis

OZET Amac: Bu calismada tek tarafli herpetik keratit tanisi ile takip edilen hastalarin kuru goz bulgularini ve gozyasi osmolaritelerini degerlendirmek ve bu bulgularin hastalik olmayan diger gozde var olup olmadigini incelemek amaclanmistir. Gerec ve Yontemler: Bu prospektif calismada klinigimiz kornea biriminde tek tarafli herpetik keratit tanisi ile takip edilen 40 hastanin keratit olan gozu (Grup 1) ve keratit olmayan diger gozu (Grup 2) ile 40 kontrol olgusunun bir gozu (Grup 3) degerlendirildi. Olgularin detayli goz muayeneleri ve gozyasi kirilma zamani (GYKZ), Schirmer testleri ve osmolarite cihazi ile olculen gozyasi osmolariteleri kaydedildi. Tum bireylerin alt ve ust kapak meibografi cekimleri yapildi ve meibomian bez kayip oranlari manuel olarak olculdu. Bulgular: Calisma grubundaki hastalarin (22 erkek, 18 kadin) ortalama yasi 53,5 ± 9,6 yil iken, kontrol grubunun (21 erkek, 19 kadin) ortalama yasi 52,4 ± 9,2 yil idi (p>0,05). Osmolarite skoru Grup 1 ve 2’de sirasiyla 307, 5± 6,9 ve 303,4 ± 7,8 mOsm/L iken Grup 3’te 295,5 ± 6,3 mOsm/L olarak bulundu (p 0,05). Sonuc: Unilateral stromal herpetik keratit, keratitin oldugu gozde daha siddetli olmak uzere, bilateral kuru goz bulgularina yol acmaktadir. Anahtar Kelimeler: Herpes Keratiti; Kuru Goz; Meibografi; Osmolarite ABSTRACT Objective: In this study, it was aimed to evaluate the dry eye findings and tear osmolarities of patients with unilateral herpetic keratitis and to investigate whether these findings were present in the fellow eyes without disease. Material and Methods: In this prospective study, 40 patients with unilateral herpetic keratitis were subdivided as eyes with keratitis (Group 1) and fellow healthy eyes (Group 2 ) and one eye of 40 control subjects were evaluated. Detailed ophthalmological examinations of the cases and tear osmolarities measured with osmolarity instrument, tear break up time (TBUT), and Schirmer test scores were recorded. All subjects underwent lower and upper lid meibography and meibomian gland loss rates were measured manually. Results: The mean age of patients in the study group (22 males, 18 females) was 53.5±9.6 years, while the mean age of the control group (21 males, 19 females) was 52.4±9.2 years (p>0.05 ). Osmolarity score was 307.5±6.9 and 303.4±7.8 in groups 1 and 2, respectively and 295.5±6.3 mOsm / L in the control group (p 0.05). Conclusion: Unilateral stromal herpetic keratitis leads to bilateral dry eye, with more severe keratitis in the affected eye. Keywords: Herpes Keratitis; Dry Eye; Meibography; Osmolarity.