A comparative genomic analysis of calcium and proton signaling/homeostasis in Aspergillus species

A large number of proteins involved in calcium and intracellular pH signaling and homeostasis have previously been discovered and characterized in Saccharomyces cerevisiae, Homo sapiens and Arabidopsis thaliana, but relatively few have been identified in Aspergillus species. The aim of this study was to identify proteins regulating the intracellular concentration of calcium ions and protons in Aspergillus spp. and compare these with other fungi. For Aspergillus spp. we identified 46, 97 and 105 putative Ca 2+ -permeable channels, cation/proton transporters and P-ATPases, respectively, the majority of them previously unknown. The subunits composing V-type H + ATPase and F0F1 ATP synthase (F-type ATPase) from Aspergillus spp. were identified. The greater redundancy of Ca 2+ -permeable channels, cation/proton exchangers