Cannabinoid-Related Adverse Events and Impairment

In addition to therapeutic benefits, cannabis also causes cognitive and psychomotor impairment in some individuals. Common acute adverse events can be cannabinoid-specific, such as those related to THC (e.g., dizziness, cognitive effects, anxiety, dry mouth) or specific to the route of administration (e.g., cough, phlegm, or bronchitis from smoking cannabis). The Diagnostic and Statistical Manual 5th Edition (DSM-5) has defined a cannabis intoxication syndrome and a cannabis intoxication delirium syndrome that may rarely result from medical cannabis use.