Insights into the cellular pharmacological properties of the BET-inhibitor OTX015/MK-8628 (birabresib), alone and in combination, in leukemia models

Lucile Astorgues-Xerri,Ramiro Vazquez,Elodie Odore,Keyvan Rezai,Carmen Kahatt,Sarah MacKenzie,Mohamed Bekradda,Marie-Magdelaine Coudé,Hervé Dombret,C. Gardin,François Lokiec,Eric Raymond,Kay Noel,Esteban Cvitkovic,Patrice Herait,Francesco Bertoni,Maria Eugenia Riveiro

Insights into the cellular pharmacological properties of the BET-inhibitor OTX015/MK-8628 (birabresib), alone and in combination, in leukemia models

2019

Lucile Astorgues-Xerri
Ramiro Vazquez
Elodie Odore
Keyvan Rezai
Carmen Kahatt
Sarah MacKenzie
Mohamed Bekradda
Marie-Magdelaine Coudé
Hervé Dombret
C. Gardin
François Lokiec
Eric Raymond
Kay Noel
Esteban Cvitkovic
Patrice Herait
Francesco Bertoni
Maria Eugenia Riveiro

The bromodomain and extra-C-terminal domain (BET) protein family is a class of epigenetic readers that recognize acetyl-lysine residues of histones, and their targeting with small molecules is a no...

Keywords:

Diabetes mellitus
Immunology
Leukemia
BET inhibitor
Pharmacology
Medicine

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