Synthesis of 1-O-(2-oxo-benzo-1,3,2-dioxaphosphaocan-2-yl)-myo-inositol and 3,5-dideoxy-1-O-(2-oxo-benzo-1,3,2-dioxaphosphaocan-2-yl)-myo-inositol as prodrugs of inositolmonophosphatase ligands

Abstract 1- O -(2-oxo-benzo-1,3,2-dioxaphosphaocan-2-yl)- myo -inositol and 3,5-dideoxy-1- O -(2-oxo-benzo-1,3,2-dioxaphosphaocan-2-yl)- myo - inositol were prepared by selective modifications of myo -inositol. Phosphorylation used the phosphite method by means of the 2( N , N -di-isopropylamino)-benzo-1,3,2-dioxaphosphaocane.