Synthesis and Characterization of Ferrocene Acetals and Evaluation of Their Antineoplastic Properties by Using Breast Cancer Cell Lines In Vitro

Two new ferrocene acetals were synthesized from a chiral diol in toluene and characterized by a range of spectroscopic techniques. The biological activities of the products were evaluated by using the breast adenocarcinoma cell lines T47D, MCF7, ZR-75-1, MD-MB-468, and MD-MB-231. In comparison with tamoxifen, the ferrocene acetals showed moderate anticancer activity in vitro for the T47D and MCF7 cell lines.