Accumulation of Phosphorylated tau in neurites is the earliest cytoskeletal abnormality in aging and Alzheimer's disease

Wei Qian, Hongwei Liang, Jianhua Shi, Jianlan Gu, Xiaolin Wu, Shibao Wang, Cheng-Xin Gong, Fei Liu, Department of Biochemistry, Medical School, Nantong University, Nantong, China; Jiangsu Key Laboratory of Neuroregeneration, Medical School, Nantong University, Nantong, China; Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA. Contact e-mail: weiqianhuang@hotmail.com