Circadian rhythm disruption exists in icu patients

Circadian rhythms, which are generated by autonomous clock genes called peripheral oscillators, has a pivotal role in harmonising the function of organs and cells of the human body, while disruption of these rhythms (i.e.chronodisruption) is accompanied with a wide spectrum of health disorders. Circadian rhythms in healthy subjects are orchestrated by the dark-time elevation of melatonin (MEL) levels peaking at dawn [1].