Reducing the incidence of chronic lung disease in very premature infants with aminophylline

2014 
Background: The objective of this study is to assess the safety and preventative effects of aminophylline on the incidence of chronic lung disease ( CLD) in very premature infants. Methods: This was a long follow‑up randomized clinical trial. The prophylactic effect of aminophylline on the incidence of CLD was investigated in very premature infants. The study group received aminophylline for the 1 st 10 days of life and control infants received no aminophylline during the 1 st 10 days of life. Results: Fifty‑two infants participated (26 aminophylline, 26 controls). Premature infants on aminophylline had clearly shorter oxygen dependency time than those in the control group. Median time of oxygen dependency was 3 (0‑9.5) days and 14 (3‑40.5) days in group A and C, respectively (P: 0.001). Incidence of CLD was significantly different between the two groups. Only two infants (8.7%) on aminophylline developed CLD, when compared to 11 infants (44.0%) , who did not receive aminophylline (P: 0.006). No side‑effects were reported in the neonates (P: 1).
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