Undifferentiated connective tissue disease presenting with vascular pattern of renal amyloidosis with carpel tunnel syndrome: A case report

Introduction: The undifferentiated connective tissue disease (UCTD) is the clinical entity where the patients share the clinical symptoms of different connective tissue diseases but do not satisfy the classification criteria of the American College of Rheumatology for a particular connective tissue disease. Case Report: A 62-year-old female was presented with multiple joint pain, Raynaud’s phenomenon, alopecia, swelling of legs, hardening of skin of the fingers of hands, and carpel tunnel syndrome. Antinuclear antibody test was moderately positive. Antibodies to double-stranded DNA and for antiphospholipid (lupus anticoagulant and anticardiolipin), anticentromere, antiScl-70, Anti-Jo1, U1-RNP Anti-Ro/SSA, Anti-La/ SSB, were negative. RA factor was also negative. Twenty-four hour urine showed nephrotic range proteinuria and renal biopsy showed vascular pattern of renal amyloidosis with changes of interstitial fibrosis. The patient was diagnosed as having UCTD with vascular pattern of renal amyloidosis with carpel tunnel syndrome with