Compounds of Acetamide and Its Analogs with Inorganic Acids: Synthesis and Properties

Quantum-chemical calculations with the MOPAC and HYPERCHEM programs and MNDO, AM1, and PM3 methods were used to identify the reaction center in the molecules of protonated acetamide and its analogs (“alkylamides”) and to determine the effect of their nature on reactivity. The results of calculations are supported by IR and UV data. The change in the reactivity of “alkylamides” during their reaction with inorganic acids is explained by the effect of the nature of a basic or acid partner.