Founding of Object Recognition Learning Paradigm in KM Mice and Its Application in Detecting Memory Impaired Properties of Compounds

The aim of the present study is to found the object recognition learning paradigm in KM mice and evaluate its potential application in safety pharmacology. The time dependent decay of object recognition memory was characterized in KM mice. Memory retention was tested 4 h or 1 h after the training and the impairment of scopolamine on the object recognition memory was assessed. The results showed a great difference between the time of exploring the two objects in the choice phase and the time of spending for novel object and for familiar object in one hour intertrial interval group, P<0.05. No difference appeared between the time of exploring the two objects in the choice phase and the time of spending for novel object and for familiar object in scopolamine group, P>0.05. The object recognition task can easily be performed in one hour intertrial interval group and scopolamine impairs the object recognition memory in KM mice. The object recognition task in KM mice, which is simple, rapid and reliable, should be applied in safety pharmacology to detect memory impaired properties of new compounds.