Review: antiemetic drugs reduce nausea in early pregnancy.

(2002) Cochrane Database Syst Rev 1, CD000145; Jewell D, Young G. . Interventions for nausea and vomiting in early pregnancy. . ;( . ): . (latest version 15 Jan 2001). . 
 QUESTION: How effective are different treatments for nausea and vomiting in early pregnancy? Studies were identified by using the search strategy of the Cochrane Pregnancy and Childbirth Review Group, which includes searches of Medline and the Cochrane Controlled Trials Register and handsearches of 38 journals.* Studies were selected if they were randomised controlled trials of any treatments to reduce nausea and vomiting in pregnancy (NVP) at up to 20 weeks of gestation. 2 reviewers independently assessed studies for quality of allocation concealment and extracted data on study methods, participant characteristics, interventions, and nausea and vomiting outcomes. 23 trials were included. Antiemetic medication reduced nausea more than did placebo (12 RCTs) but caused more drowsiness and sleepiness (4 RCTs) (table). 3 trials compared Bendectin with placebo …