Dexmedetomidine combined with therapeutic hypothermia is associated with cardiovascular instability and neurotoxicity in a piglet model of perinatal asphyxia

M Ezzati,G Kawano,Eridan Rocha-Ferreira,Daniel Alonso-Alconada,Jane Hassell,K Broad,I Fierens,Bobbi Fleiss,A Bainbridge,David Price,Pardis Kaynezhad,Brian Anderson,Mariya Hristova,Ilias Tachtsidis,Xavier Golay,Pierre Gressens,Robert D. Sanders,Nicola J. Robertson

Dexmedetomidine combined with therapeutic hypothermia is associated with cardiovascular instability and neurotoxicity in a piglet model of perinatal asphyxia

2017

M Ezzati
G Kawano
Eridan Rocha-Ferreira
Daniel Alonso-Alconada
Jane Hassell
K Broad
I Fierens
Bobbi Fleiss
A Bainbridge
David Price
Pardis Kaynezhad
Brian Anderson
Mariya Hristova
Ilias Tachtsidis
Xavier Golay
Pierre Gressens
Robert D. Sanders
Nicola J. Robertson

The selective α2-adrenoreceptor agonist dexmedetomidine has shown neuroprotective, analgesic, anti-inflammatory, and sympatholytic properties that may be beneficial in neonatal encephalopat

Keywords:

Instability
Agonist
Sympatholytic
Dexmedetomidine
Neonatal encephalopathy
Anesthesia
Biology
Neurotoxicity
Perinatal asphyxia
Neuroprotection
Hypothermia

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