Advances in Research on Pathological Mechanism and Therapeutic Drugs for Coronavirus Disease 2019/ 新型冠状病毒肺炎病理机制及治疗药物研究进展

Coronavirus disease 2019 has become a pandemic The transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is strong, and the population is generally susceptible The virus enters target cells via angiotensin-converting enzyme 2 as a cellular receptor Spike protein is activated by serine protease TMPRSS2 The virus can cause damage to multiple organs, and there are currently no specific drugs for this virus However, several assessments and studies have been carried out At present, the epidemic situation in China has been effectively controlled However, the number of infections abroad has increased rapidly Therefore, the epidemic situation in foreign countries is still very serious The global epidemic prevention and control work is facing huge challenges In order to effectively prevent and treat coronavirus disease 2019, this article reviews the etiology, pathological mechanism, pathological manifestations, and development of therapeutic drugs for coronavirus disease 2019