ZNC(C)PR Induces Phosphorylation of CREB in Rat Hippocampus.

ZNC(C)PR can facilitate the learning and memory in ra t. Transgenic experiments have revealed that long term memory depended on cycli c AMP response element binding protein, CREB. CREB phosphorylation at serine 1 33 is essential for its transcriptional activity. Here, it was demonstrated th at ZNC(C)PR could induce CREB phosphorylation at serine 133 in both rat hippoca mpus and rat hippocampus slices. ZDC(C)PR[antagnist of ZNC(C)PR], PTX(inhibito r of G o/G i protein coupled receptor), GF109203x(inhihitor of PKC), PD98059( inhibitor of MAPK ) but not KN 62(inhibitor of CaMKII) could inhibit the ph osphorylation of CREB induced by ZNC(C)PR.