EVALUATION OF THE EFFECT OF MELOXICAM ON BLOOD PRESSURE RESPONSE IN RELATION TO HIS PROHYPERTENSIVE EFFECT

The influence of Meloxicam on the level of blood pressure was evaluated among patients suffering from hypertension and getting antihypertensive therapy, as well as among patients without diseases of the cardiovascular system, in relation to its pro-hypertensive effect. Through the retrospective analysis of medical histories, we studied levels of blood pressure, measured by the Korotkov’s method, before and after 3 months of taking Meloxicam in a dose of 7.5 mg / day. It was found that long-term medication of Meloxicam led to an increase of blood pressure indicators, both in patients without established diseases of the cardiovascular system, and in patients with the hypertension and an average total cardiovascular risk, who are regularly taking antihypertensive pills to achieve target blood pressure. In these cases, preference should be given to drugs that have the least effect on blood pressure indicators, such as Naproxen and Celecoxib (in the absence of IHD). Dihydropyridine calcium channel blockers should be considered as the mediсation of choice for the hypertension in patients who need long-term NSAID therapy.