A convenient method for preparing aromatic ketones from acyl chlorides and arylboronic acids via Suzuki–Miyaura type coupling reaction

2003 
Abstract Aromatic ketones are synthesized efficiently via palladium-catalyzed cross-coupling reaction of boronic acids with acyl chlorides in the presence of K 3 PO 4 hydrate in toluene. This allows the use of aliphatic acyl chlorides as the starting material. Hydrated water plays a significant role as an H 2 O source to activate the catalytic system.
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