Alpha-amylase Inhibitory Activity of Sitopaladi Churna: An Ayurvedic Formula

Sitopaladi Churna is an ayurvedic formula, traditionally used as anti-inflammatory, carminative, sedative, expectorant, anti-infective, and various respiratory disorders. The aim of the present study is to screening for alpha amylase (α-amylase) inhibition activity of aqueous extract of Sitopaladi Churna. In vitro α-amylase inhibition activity of Sitopaladi Churna was screened by the 3,5-dinitrosalicylic acid method. Sitopaladi Churna showed potent (α-amylase) inhibitory activity with an IC50  - 46.38 µ g/ml. Thus, Sitopaladi Churna may consider as a remedy for diabetes and other  insulin  resistance-related  diseases;  however,  animal  and  human  studies  are  needed  to confirm this activity.