Optimization of Tablet Friability, Maximum Attainable Crushing Strength, Weight Variation and In Vitro Dissolution by Establishing In-Process Variable Controls

AbstractThe level of intragranular microcrystalline cellulose, volume of granulating water, granulation moisture content and tablet crushing strength were used as in-process variables for optimizing tablet friability, maximum attainable crushing strength, weight variation and in vitro dissolution. A computer optimized experimental design (COED) allowed optimal characterization of the variables by designing 22 experiments. The results were analyzed by means of a general quadratic response surface model. Response surfaces were generated for tablet friability, maximum attainable crushing strength, weight variation and in vitro dissolution as a function of the in-process variables. The study provided a useful method in setting optimum ranges for the in-process variables in order to optimize the important tablet parameters.