371. A comparative study of two immunoassays of placental growth factor

Objective To compare the results obtained from use of two commercially available immunoassays of maternal placental growth factor (PlGF) in a multiple pregnancy cohort. Methods Results obtained using the Triage® PlGF Test (Alere) were compared against those from the Quantikine® ELISA PlGF kit (RD p 0.001). Discussion Although the two assays correlate well, there is a significant difference in the actual PlGF values obtained. This is likely due to measurement of differing isoforms of PlGF in each assay. The ELISA kits may be detecting PIGF-2 & PIGF-3 while PIGF-4 remains untested. This highlights the importance of developing a unique reference range for any commercial PlGF test before introducing it into the clinical setting.