Effects of Quetiapine and Sulpiride on Serum Glucose and Lipids Metabolism in Patients with Schizophrenia

Objective:To investigate the effects of quetiapine and sulpiride on body weight and serum glucose and lipid metabolism in patients with schizophrenia.Methods:A total of 173 inpatients with schizophrenia from 5 hospitals were randomly divided into quetiapine group(90 cases) and sulpiride group(80 cases) in this multicenter study.The Treatment Emergent Symptom Scale(TESS) ,the fasting blood glucose and serum lipids and the body weight were measured before and after the treatment.Results:(1) There was no change in body weight,serum glucose and lipids in quetiapine group after treatment.(2) After 4-week and 8-week treatment,body weight [(61.14±7.37) kg vs.(64.50±7.58) kg],serum glucose level [(4.33±0.36) mmol/L vs.(4.59±0.39) mmol/L]and triglyceride level [(0.97±0.51) mmol/L vs.(1.50±0.87) mmol/L] were significantly higher than those before treatment in sulpiride group(Ps0.05).(3) After 8-week treatment,body weight,serum glucose and triglyceride levels in sulpiride group were significantly higher than those in quetiapine group.Conclusion:There are obvious effects on lipid metabolism after sulpiride treatment but not quetiapine.