Lamina cribrosa and peripapillary scleral histomorphometry in myopic and non myopic glaucomatous chinese eyes
2008
Purpose To study the glaucomatous optic nerve head in Chinese eyes.
Methods The histomorphometric investigation included a Normal group (non-highly myopic eyes) of 40 human globes enucleated due to a malignant choroidal melanoma, a Glaucomatous group (non-highly myopic eyes) of 55 eyes enucleated due to painful secondary angle-closure glaucoma, and a Highly Myopic Glaucomatous group of 26 glaucomatous globes with an axial length >26.5 mm. Anterior-posterior histological sections through the pupil and the optic disc were morphometrically evaluated and compared.
Results The lamina cribrosa was significantly (P<0.001) thicker in the Normal group than in the Glaucomatous group, in which it was significantly (P<0.001) thicker than in the Highly Myopic Glaucomatous group. The lamina cribrosa thickness decreased significantly (P<0.001) with increasing axial length and presence of glaucoma (p<0.001). The peripapillary scleral thickness close to the optic nerve scleral canal and just outside of the optic nerve meninges decreased significantly with increasing axial length (P=0.04 and P=0.02, respectively). The peripapillary scleral thickness did not vary significantly between the Glaucomatous group and the Normal Group. The distance between the intraocular space and cerebrospinal fluid space was (p<0.001) shorter in the two glaucomatous groups than in the Normal group.
Conclusion Lamina cribrosa thickness and peripapillary sclera thickness decreased significantly with axial length, in addition to a glaucoma-related thinning of the lamina cribrosa. Within non-highly myopic eyes, the peripapillary sclera thickness did not vary significantly between glaucomatous eyes and normal eyes.
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