The use of two alpha blocking agents, phenoxybenzamine and phentolamine, in ointment and injection form to improve skin flap survival in rats

: Two alpha blocking agents, phenoxybenzamine and phentolamine, were tested to see if their use improved skin flap survival in rats. The agents were used in two ways: in local injections and topical applications. The results showed an increased duration of flap viability with both modalities, but the topical application was the most effective.