Effect of 6 Weeks of Low-volume High-intensity Interval Training on Antioxidant Defense and Aerobic Power in Female Survivors of Breast Cancer

Introduction: Antioxidant defense and aerobic fitness of patients with breast cancer are not favorable in the disease, treatment and post-treatment phases. Considering the likely role of exercise training on the antioxidant status, the present study aimed to investigate the effect of 6 weeks of low-volume high-intensity interval training (LVHIIT) on antioxidant defense and aerobic power in female survivors of breast cancer. Subjects & Methods: In this clinical trial study, 20 breast cancer survivors (mean age 44.90±2.82 years old) randomly divided into experimental (n=10) and control (n=10) groups. The experimental group participated in a six weeks of LVHIIT (three session per week). Total antioxidant capacity and Malondialdehyde levels were measured by ELISA kits and aerobic power by Balke Protocol. Data were analyzed using paired and independent t-test. Results: Total antioxidant capacity significantly improved (P=0.007) and Malondialdehyde levels significantly decreased (P=0.009). Also, aerobic power significantly improved (P=0.001). Conclusion: Six weeks of low-volume high-intensity interval training can improve the body's antioxidant status and aerobic power in patients with breast cancer and as a result, play an important role in prevention of breast cancer recurrence.