A method for reducing the fucose content of a recombinant protein

The invention in transformed with an expression vector expressing a recombinant protein animal cells, FUCA1, FUCA1 mutant, FUCA2 or FUT8 localization to overexpress the domain fragment, or localization domain of FUT8 fragment of FUCA1 fragment, FUCA1 fragment mutant or FUCA2 It relates to a process for by expressing a fusion protein fused to fragments, reducing the fucose content of the expressed recombinant proteins, according to the method of the present invention, when expressing the antibody in recombinant protein Fu of the antibody constant region (Fc region) possible to reduce the content of course it is possible to improve the therapeutic efficacy of the antibody.