A Panel of Rabbit Monoclonal Antibody Marker for Prostate Cancer

AbstractTumor markers are useful in identification of tumor origin and in analysis of the biological characteristics of specific tumor. The objective of this study was to determine the immunohistochemical application of a panel of rabbit monoclonal antibodies against human prostate tumor specific antigens Alpha-methylacyl-CoA racemase (AMACR or P504s), androgen receptor (AR), ETS-related gene (ERG), prostatic acid phosphatase (PAP) and prostate specific antigen (PSA) on formalin-fixed and paraffin-embedded tissues. These antibodies were developed with a unique and proprietary RabMAb® technology, designated as EP clone product line (EP Clones™). All the antibodies showed excellent signal-to-noise ratio in immunohistochemical staining on formalin-fixed and paraffin-embedded tissues. Rabbit monoclonal antihuman AMACR, AR, ERG, PAP and PSA are valuable for immunohistochemical analysis of prostate cancer.