Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic?

Apolipoprotein A-I (apoA-I, a single chain of 243 amino acids) is the major structural and functional protein on plasma high-density lipoprotein (HDL, a.k.a. “good cholesterol”). ApoA-I and HDL rem...