Are Erk, Btk, and PECAM-1 major players in GPIb signaling? The challenge of unraveling signaling events downstream of platelet GPIb

Several recently published studies in Blood have attempted to unravel the signaling events operating downstream of GPIb.[1][1][⇓][2]–[3][3] One of these studies by Garcia et al[1][1] examined the role of Erk in promoting VWF/GPIb-dependent activation of integrin αIIbβ3 in platelets. These