Étude comparée du métabolisme, in vitro, de la [6, 7-3H] estrone et du [6, 7-3H] estrone-3-sulfate par le foie maternel et fœtal du cobaye

Summary The metabolism of [6,7- 3 H]estrone and of [6,7 3 H] estrone-3-sulfate have been comparatively studied in the maternal and fetal guinea-pig livers. The appearance of estradiol-17β resulting from the activity of the 17β-hydroxysteroid-dehydrogenase is more important in the fetal than in the maternal hepatic tissue. This suggests the direct transformation of estrone-3-sulfate into estradiol-3-sulfate in the fetus. After incubation of the [ 3 H] estrone, there is an abundant hepatic conjugation. The glycuroconjugated components are predominant, as well in the maternal as in the fetal hepatic tissue. For the latter-one the sulfoconjugation is inexistant. The sulfatasic activity shown after the incubation of [ 3 H] estrone-3-sulfate is very low in the fetal hepatic tissue; in contrast, this activity is higher in the maternal tissue.