Radiation-Induced Alkylation of Quinoline Derivatives with Alcohol.

Gamma-irradiation of quinoline and its derivatives in alcohols brings about alkylation at the 2- or 4-position of pyridine ring. Hydroxyalkyl radicals play important roles in the radiation-induced alkylation with alcohol. The radiation-induced substitution of CF3CH2– and CF3CH(OH)– for H in pyridine and pyrimidine rings occurs in low yields.