Antifibrotic cardioprotection of berberine via downregulating myocardial IGF-1 receptor-regulated MMP-2/MMP-9 expression in diabetic rats

Guohua Li,Wenjuan Xing,Min Zhang,Feng-Hao Geng,Hongyan Yang,Haifeng Zhang,Xing Zhang,Jia Li,Ling Dong,Feng Gao

Antifibrotic cardioprotection of berberine via downregulating myocardial IGF-1 receptor-regulated MMP-2/MMP-9 expression in diabetic rats

2018

Guohua Li
Wenjuan Xing
Min Zhang
Feng-Hao Geng
Hongyan Yang
Haifeng Zhang
Xing Zhang
Jia Li
Ling Dong
Feng Gao

Berberine downregulated IGF-1 receptor expression and matrix metalloproteinase-2/matrix metalloproteinase-9 levels in cardiac fibroblasts and thus inhibited fibroblast differentiation and collagen ...

Keywords:

Diabetic cardiomyopathy
Biochemistry
Cardiac fibrosis
Matrix metalloproteinase
Fibroblast
Berberine
Cardioprotection
Diabetes mellitus
Biology
Receptor
Pharmacology
receptor expression

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