Transdermal glyceryl trinitrate for prevention of post-ERCP pancreatitis: A randomized double-blind trial
2003
Abstract Background: Pancreatic sphincter hypertension increases the risk of pancreatitis in patients undergoing ERCP. Glyceryl trinitrate reduces sphincter of Oddi pressure. This study tested the hypothesis that transdermal glyceryl trinitrate could be effective in the prevention of post-ERCP pancreatitis. Methods: One hundred forty-four patients undergoing ERCP were randomized: 71 received a 15-mg glyceryl trinitrate patch (glyceryl trinitrate group) and 73 a placebo patch (control group). Results: In the control group, post-ERCP pancreatitis developed in 11 patients versus 3 in the glyceryl trinitrate group ( p p p Conclusions: The results of this study suggest that use of a transdermal glyceryl trinitrate patch protects against post-ERCP pancreatitis. (Gastrointest Endosc 2003;57:1-7.)
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