Growth of the dominant follicle is similar to normal in patients with gonadotrophin-stimulated polycystic ovary syndrome exhibiting monofollicular development during a decremental dose regimen

The aim of this study was to investigate the late follicular phase of seven gonadotrophin-treated patients with polycystic ovary syndrome (PCOS) exhibiting monofollicular growth and to compare developmental characteristics with the dominant follicle in seven regularly cycling control women. Daily serum follicle-stimulating hormone (FSH) levels in patients with PCOS decreased more rapidly compared to controls (-0.3±0.2 IU/day in controls versus -0.7±0.4 IU/day in PCOS; p<0.02). No statistically significant differences were seen in daily increase (30% in controls and PCOS) and mean peak levels (825±94 pmol/l in controls versus 937±231 pmol/l in PCOS) of oestradiol (B 2 ) serum levels when comparing both groups