How doppelgänger effects in biomedical data confound machine learning.
2021
Abstract Machine learning (ML) models have been increasingly adopted in drug development for faster identification of potential targets. Cross-validation techniques are commonly used to evaluate these models. However, the reliability of such validation methods can be affected by the presence of data doppelgangers. Data doppelgangers occur when independently derived data are very similar to each other, causing models to perform well regardless of how they are trained (i.e., the doppelganger effect). Despite the abundance of data doppelgangers in biomedical data and their inflationary effects, they remain uncharacterized. We show their prevalence in biomedical data, demonstrate how doppelgangers arise, and provide proof of their confounding effects. To mitigate the doppelganger effect, we recommend identifying data doppelgangers before the training-validation split.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
26
References
1
Citations
NaN
KQI