Haloperidol reduction can be assayed in human red blood cells

One metabolite of haloperidol present in plasma is "reduced haloperidol." This study demonstrates that human red blood cells are capable of converting haloperidol to reduced haloperidol in vitro. The reductase involved requires NADPH, as does haloperidol (ketone) reductase in human liver cytosol.Key words: haloperidol reductase, human red blood cells, ketone reductase.