Antisweet Saponins from Gymnema sylvestre
2001
Three new oleanane-type triterpene glycosides (1−3), along with the sodium salt of alternoside II (4), were isolated from an ethanol extract of the leaves of Gymnema sylvestre. The structures of these new saponins were identified as 21β-O-benzoylsitakisogenin 3-O-β-d-glucopyranosyl(1→3)-β-d-glucuronopyranoside (1), the potassium salt of longispinogenin 3-O-β-d-glucopyranosyl(1→3)-β-d-glucuronopyranoside (2), and the potassium salt of 29-hydroxylongispinogenin 3-O-β-d-glucopyranosyl(1→3)-β-d-glucuronopyranoside (3). The aglycon of 3, gymnemagenol (3a), was characterized as 3β,16β,28,29-tetrahydroxyolean-12-ene. Structure elucidation was accomplished by interpretation of NMR (DQF-COSY, HMQC, and HMBC) results, FABMS, and hydrolysis. Saponin 1 and the sodium salt of alternoside II (4) exhibited antisweet activity.
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