Additional Commercial Gammaglobulin Preparations Found with Antibody to Human Immunodeficiency Virus

Colleagues?Abacioglu and Okuyan [1] recently reported the presence of human immunodeficiency virus (HIV) antibody in two vials of commercial gammaglobulin tested in June 1987 (lot no. X-001, Landerlan, S. A. Laboratory, Madrid, Spain). In April 1988 our laboratory obtained two vials of commercial gammaglobulin (lot X113, Laboratories Hubber, S.A., Barcelona, Spain, and lot X-002, Laboratorios Landerlan, S.A., Madrid, Spain) from Li Lantian (Baoding Antiepidemic Station, Hebei Province Public Health Department, People's Republic of China), who found them to be HIVantibody-reactive using the Abbott ELISA procedure (Abbott Laboratories, North Chicago, IL). These products were subsequently tested in our laboratory; the results are shown in table 1. Both preparations were found to be HIVantibody-reactive by the DuPbnt ELISA procedure (Wilmington, DE) and were subsequently studied by the Western blot assay described previously [2]. Using the interpretive criteria of the Association of State and Territorial Public Health Laboratory Directors and the Centers for Disease Control [3], the presence of the p24 and gpl60 bands in both of the gammaglobulin preparations tested are to be considered Western-blot-positive, indicating the presence of antibody to HTV. Attempts to culture HIV from these preparations yielded no infectious virus.