Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton
1999
A still unknown tricyclic heterocyclic system (5) was synthesized from 6-hydroxy-2-methylpyridazin-3-one and its structure identified as 2,8-dichloro-6-methylpyrrolo[1,2-b:3,4-d']dipyridazin-5(6H)-one by spectroscopic investigations. Selective condensation of 5 with 2-[4-(2-substituted-phenyl)piperazin-1-yl]ethylamine gave the 2-arylpiperazinylethylamino-8-chloro derivatives 6a-c, which were investigated in binding studies toward the three α 1 -adrenergic and 5-HT 1A -serotonergic receptor subtypes. They displayed high potency on all the assays and some selectivity for α 1a and α 1d subtypes.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
7
References
11
Citations
NaN
KQI