Clinicopathologic analysis of primary pure squamous cell carcinoma of the breast

Objective To analyze the clinicopathologic characteristics and treatment method for primary pure squamous cell carcinoma of the breast. Methods Twelve patients with primary squamous cell carcinoma of the breast pathologically confirmed were retrospectively reviewed. The clinical characteristics, diagnosis, treatment and prognosis were analyzed. Results All 12 patients were women with median age of 50 years (44-76 years). The patients all presented a single mass in the breast on presentation. The diameter ranged from 2.5 cm to 10.0 cm in diameter. All of the patients had undergone surgical resection. There were 6 cases in stage Ⅱ a, 2 in Ⅱ b, 2 in Ⅲ a and 2 in Ⅲ b according to the TNM staging system of AJCC and UICC. Ten of the 12 cases were followed-up from 4 months to 189 months. Conclusion Primary squamous cell carcinoma of the breast is often in need of diagnosis by exclusion, but can be initially confirmed by fine needle aspiration. Presently, no standard therapy can be recommended in practice. The prognosis is controversial.