CARDIOVASCULAR EFFECTS INDUCED BY LINALOOL AFTER SUBCHRONIC TREATMENT OF SPONTANEOUSLY HYPERTENSIVE RATS

IntroductionLinalool (LIN) is an alcoholic monoterpene with biological activities previously described. This study in order to evaluate the cardiovascular effects in vivo subchronic treatment of spontaneously hypertensive rats (SHR) is focusing on antihypertensive properties of linalool. MethodsAll experiments were performed with SHR aged 9–12 weeks and (−)-linalool (≥ 97 % purity) was solubilized in cremophor in a ratio of 2:1 and diluted with physiological saline solution (100 mg/kg) and controls solutions captopril (30 mg/kg) and vehicle (saline + cremophor) were administered daily for 21 days by orogastric injections. Each 5 days the arterial pressure and the heart rate were measured by tail cuff method. At the end of treatment, mesenteric artery was isolated to reactivity tests and the heart was removed and placed in an oven to dry at 60° C, for 24 to 48 hours, to obtain the dry weight. ResultsAnimals treated with linalool, vehicle and captopril showed no statistically significant differences at the ...